Treatment of chronic hepatitis C with faldaprevir and deleobuvir

23 August, 2018

En agosto la revista New England Journal of Medicine publica un artículo sobre el tratamiento libre de interferón de la hepatitis crónica C con Faldaprevir (inhibidor de la proteasa del virus) y Deleobuvir (inhibidor de la polimerasa vírica).

A total of 362 patients with hepatitis C virus and genotype 1 who had not been treated previously were divided into 5 groups and received: 120 mg daily of Faldaprevir and 600 mg of Deleobuvir three times daily along with ribavirin for 16, 28 or 40 weeks Another group received 120 mg daily of Faldaprevir and 600 mg of Deleobuvir twice daily (instead of 3 times a day) together with ribavirin for 28 weeks and the last group was treated with 120 mg / day of Faldaprevir and 600 mg of Deleobuvir three times a day for 28 weeks but without ribavirin.

At 12 weeks after the end of treatment, the percentage of patients with sustained virological response in the groups receiving triple therapy ranged from 52 to 69% compared to 39% of patients who received only Faldaprevir + Deleobuvir. The percentage of sustained response was higher in patients with genotype 1b of the virus (85%) than in those of genotype 1a (47%). Also, patients with the CC genotype in the interleukin 28B gene responded better (84%) than those with the TC or TT genotype (64%). The most common side effects of the treatment were pruritus, photosensitivity, nausea, vomiting and diarrhea. In summary, these new treatments without interferon are promising but it is necessary to improve their effectiveness since with the current triple therapy (interferon + ribavirin + protease inhibitors) healing is achieved in 70% patients.

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