{"id":4643,"date":"2025-05-17T21:27:15","date_gmt":"2025-05-17T21:27:15","guid":{"rendered":"https:\/\/fehv.org\/?p=4643"},"modified":"2025-05-17T21:27:17","modified_gmt":"2025-05-17T21:27:17","slug":"efficacy-resmetirom-clinical-practice-side-effects","status":"publish","type":"post","link":"https:\/\/fehv.org\/en\/efficacy-resmetirom-clinical-practice-side-effects\/","title":{"rendered":"Efficacy of resmetirom in clinical practice and side effects"},"content":{"rendered":"\n<p style=\"font-size:18px\">Resmetirom, a thyroid hormone beta receptor agonist, has demonstrated its usefulness for the <strong>treatment of steatohepatitis<\/strong> (fatty liver with inflammation and destruction of liver cells), as we have discussed previously. Since April 2024, this drug has been commercially available in the United States under the name of Rezdiffra.<\/p>\n\n\n\n<p style=\"font-size:18px\">In addition to the clinical trials conducted with resmetirom, a study on the efficacy of this drug in clinical practice has been published in the <strong><a href=\"https:\/\/www.journal-of-hepatology.eu\/\" target=\"_blank\" rel=\"noreferrer noopener\">Journal of Hepatology<\/a><\/strong>. A total of 83 patients with steatohepatitis (grade 2-3 fibrosis out of 4) who were being treated with 80-100 mg of resmetirom daily by different hepatologists were included. <\/p>\n\n\n\n<p style=\"font-size:18px\">Resmetirom has been shown to <strong>resolve steatohepatitis in 25% to 30% of patients<\/strong>. It also induces at least a 1-grade improvement in fibrosis and significantly reduces the amount of liver fat in just 12 to 36 weeks.<\/p>\n\n\n\n<h2 class=\"wp-block-heading mt-5 mb-4\" id=\"h-resmetirom-side-effects\"><strong>Resmetirom side effects<\/strong><\/h2>\n\n\n\n<p style=\"font-size:18px\">Regarding side effects of resmetirom, it is generally well tolerated, although 24% of patients experienced diarrhea, 18% nausea, 15% abdominal pain, and 5% vomiting. Additionally, 15% suffered rash, 6% dizziness, and 5% headache. Approximately 16% of patients had to discontinue treatment, primarily due to side effects.<\/p>\n\n\n\n<p style=\"font-size:18px\">In summary, resmetirom is a new drug useful for the treatment of steatohepatitis, although as of May 2025, it is not yet approved for use in Europe. In the United States, the price of the drug is $4,200 per month, making it an <strong>extremely expensive treatment<\/strong> ($50,400 per year).<\/p>\n\n\n\n<p style=\"font-size:18px\">Resmetirom is the first drug approved specifically for the treatment of fatty liver with fibrosis (steatohepatitis), and others are under evaluation for this indication (obeticholic acid). <strong><a href=\"\/en\/especialista\/dr-vicente-carreno\/\">Dr. Carre\u00f1o<\/a><\/strong> and the Foundation&#8217;s medical team will consider resmetirom for the treatment of steatohepatitis as soon as it becomes available in Spain.<\/p>\n","protected":false},"excerpt":{"rendered":"Resmetirom is the first approved drug for steatohepatitis, effective in reducing liver fat and fibrosis. Available in the U.S., it awaits approval in Europe due to high cost and limited access.","protected":false},"author":1,"featured_media":4641,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[623,621,624],"tags":[],"class_list":["post-4643","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-fatty-liver","category-news","category-treatments"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.7 (Yoast SEO v23.7) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Efficacy of resmetirom in clinical practice and side effects - Cl\u00ednica FEHV<\/title>\n<meta name=\"description\" content=\"Resmetirom for the treatment of steatohepatitis shows clinical promise by reducing liver fat and fibrosis.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fehv.org\/en\/efficacy-resmetirom-clinical-practice-side-effects\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Efficacy of resmetirom in clinical practice and side effects\" \/>\n<meta property=\"og:description\" content=\"Resmetirom for the treatment of steatohepatitis shows clinical promise by reducing liver fat and fibrosis.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/fehv.org\/en\/efficacy-resmetirom-clinical-practice-side-effects\/\" \/>\n<meta property=\"og:site_name\" content=\"Cl\u00ednica FEHV\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/pages\/Fundacion%20Para%20el%20Estudio%20de%20las%20Hepatitis%20Virales\/228605694153917\/\" \/>\n<meta property=\"article:published_time\" content=\"2025-05-17T21:27:15+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-05-17T21:27:17+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/fehv.org\/wp-content\/uploads\/2025\/05\/resmetirom-hepatitis.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1280\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"ifranco\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"ifranco\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/fehv.org\/en\/efficacy-resmetirom-clinical-practice-side-effects\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/fehv.org\/en\/efficacy-resmetirom-clinical-practice-side-effects\/\"},\"author\":{\"name\":\"ifranco\",\"@id\":\"https:\/\/fehv.org\/#\/schema\/person\/5e92ddd4a04516dab21fb5b6fa90b777\"},\"headline\":\"Efficacy of resmetirom in clinical practice and side effects\",\"datePublished\":\"2025-05-17T21:27:15+00:00\",\"dateModified\":\"2025-05-17T21:27:17+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/fehv.org\/en\/efficacy-resmetirom-clinical-practice-side-effects\/\"},\"wordCount\":280,\"publisher\":{\"@id\":\"https:\/\/fehv.org\/#organization\"},\"image\":{\"@id\":\"https:\/\/fehv.org\/en\/efficacy-resmetirom-clinical-practice-side-effects\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/fehv.org\/wp-content\/uploads\/2025\/05\/resmetirom-hepatitis.jpg\",\"articleSection\":[\"Fatty liver\",\"News\",\"Treatments\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/fehv.org\/en\/efficacy-resmetirom-clinical-practice-side-effects\/\",\"url\":\"https:\/\/fehv.org\/en\/efficacy-resmetirom-clinical-practice-side-effects\/\",\"name\":\"Efficacy of resmetirom in clinical practice and side effects - 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