{"id":1724,"date":"2018-08-23T18:29:29","date_gmt":"2018-08-23T18:29:29","guid":{"rendered":"https:\/\/fehv.org\/?p=1724"},"modified":"2018-08-23T18:30:14","modified_gmt":"2018-08-23T18:30:14","slug":"treatment-of-chronic-hepatitis-c-with-faldaprevir-and-deleobuvir","status":"publish","type":"post","link":"https:\/\/fehv.org\/en\/treatment-of-chronic-hepatitis-c-with-faldaprevir-and-deleobuvir\/","title":{"rendered":"Treatment of chronic hepatitis C with faldaprevir and deleobuvir"},"content":{"rendered":"<p>A total of 362 patients with hepatitis C virus and genotype 1 who had not been treated previously were divided into 5 groups and received: 120 mg daily of Faldaprevir and 600 mg of Deleobuvir three times daily along with ribavirin for 16, 28 or 40 weeks Another group received 120 mg daily of Faldaprevir and 600 mg of Deleobuvir twice daily (instead of 3 times a day) together with ribavirin for 28 weeks and the last group was treated with 120 mg \/ day of Faldaprevir and 600 mg of Deleobuvir three times a day for 28 weeks but without ribavirin.<\/p>\n<p>At 12 weeks after the end of treatment, the percentage of patients with sustained virological response in the groups receiving triple therapy ranged from 52 to 69% compared to 39% of patients who received only Faldaprevir + Deleobuvir. The percentage of sustained response was higher in patients with genotype 1b of the virus (85%) than in those of genotype 1a (47%). Also, patients with the CC genotype in the interleukin 28B gene responded better (84%) than those with the TC or TT genotype (64%). The most common side effects of the treatment were pruritus, photosensitivity, nausea, vomiting and diarrhea. In summary, these new treatments without interferon are promising but it is necessary to improve their effectiveness since with the current triple therapy (interferon + ribavirin + protease inhibitors) healing is achieved in 70% patients.<\/p>\n","protected":false},"excerpt":{"rendered":"En agosto la revista New England Journal of Medicine publica un art\u00edculo sobre el tratamiento libre de interfer\u00f3n de la hepatitis cr\u00f3nica C con Faldaprevir (inhibidor de la proteasa  del virus) y Deleobuvir (inhibidor de la polimerasa v\u00edrica).","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[624],"tags":[],"class_list":["post-1724","post","type-post","status-publish","format-standard","hentry","category-treatments"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.6 (Yoast SEO v27.6) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Treatment of chronic hepatitis C with faldaprevir and deleobuvir - Cl\u00ednica FEHV<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fehv.org\/en\/treatment-of-chronic-hepatitis-c-with-faldaprevir-and-deleobuvir\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Treatment of chronic hepatitis C with faldaprevir and deleobuvir\" \/>\n<meta property=\"og:description\" content=\"En agosto la revista New England Journal of Medicine publica un art\u00edculo sobre el tratamiento libre de interfer\u00f3n de la hepatitis cr\u00f3nica C con Faldaprevir (inhibidor de la proteasa del virus) y Deleobuvir (inhibidor de la polimerasa v\u00edrica).\" \/>\n<meta property=\"og:url\" content=\"https:\/\/fehv.org\/en\/treatment-of-chronic-hepatitis-c-with-faldaprevir-and-deleobuvir\/\" \/>\n<meta property=\"og:site_name\" content=\"Cl\u00ednica FEHV\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/clinicaFEHV\/\" \/>\n<meta property=\"article:published_time\" content=\"2018-08-23T18:29:29+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2018-08-23T18:30:14+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/fehv.org\/wp-content\/uploads\/2018\/07\/tratamiento_hepatitis_cronica.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"350\" \/>\n\t<meta property=\"og:image:height\" content=\"350\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"ifranco\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"ifranco\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/fehv.org\\\/en\\\/treatment-of-chronic-hepatitis-c-with-faldaprevir-and-deleobuvir\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/fehv.org\\\/en\\\/treatment-of-chronic-hepatitis-c-with-faldaprevir-and-deleobuvir\\\/\"},\"author\":{\"name\":\"ifranco\",\"@id\":\"https:\\\/\\\/fehv.org\\\/#\\\/schema\\\/person\\\/5e92ddd4a04516dab21fb5b6fa90b777\"},\"headline\":\"Treatment of chronic hepatitis C with faldaprevir and deleobuvir\",\"datePublished\":\"2018-08-23T18:29:29+00:00\",\"dateModified\":\"2018-08-23T18:30:14+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/fehv.org\\\/en\\\/treatment-of-chronic-hepatitis-c-with-faldaprevir-and-deleobuvir\\\/\"},\"wordCount\":217,\"publisher\":{\"@id\":\"https:\\\/\\\/fehv.org\\\/#organization\"},\"articleSection\":[\"Treatments\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/fehv.org\\\/en\\\/treatment-of-chronic-hepatitis-c-with-faldaprevir-and-deleobuvir\\\/\",\"url\":\"https:\\\/\\\/fehv.org\\\/en\\\/treatment-of-chronic-hepatitis-c-with-faldaprevir-and-deleobuvir\\\/\",\"name\":\"Treatment of chronic hepatitis C with faldaprevir and deleobuvir - 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